197 research outputs found

    Power and timing modelling, optimisation and simulation

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    Editorial.Peer Reviewe

    Power and timing modelling, optimisation and simulation

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    Dataflow acceleration of Smith-Waterman with Traceback for high throughput Next Generation Sequencing

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    Smith-Waterman algorithm is widely adopted bymost popular DNA sequence aligners. The inherent algorithmcomputational intensity and the vast amount of NGS input datait operates on, create a bottleneck in genomic analysis flows forshort-read alignment. FPGA architectures have been extensivelyleveraged to alleviate the problem, each one adopting a differentapproach. In existing solutions, effective co-design of the NGSshort-read alignment still remains an open issue, mainly due tonarrow view on real integration aspects, such as system widecommunication and accelerator call overheads. In this paper, wepropose a dataflow architecture for Smith-Waterman Matrix-filland Traceback alignment stages, to perform short-read alignmenton NGS data. The architectural decision of moving both stages onchip extinguishes the communication overhead, and coupled withradical software restructuring, allows for efficient integration intowidely-used Bowtie2 aligner. This approach delivers×18 speedupover the respective Bowtie2 standalone components, while our co-designed Bowtie2 demonstrates a 35% boost in performance

    BrainFrame: A node-level heterogeneous accelerator platform for neuron simulations

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    Objective. The advent of high-performance computing (HPC) in recent years has led to its increasing use in brain studies through computational models. The scale and complexity of such models are constantly increasing, leading to challenging computational requirements. Even though modern HPC platforms can often deal with such challenges, the vast diversity of the modeling field does not permit for a homogeneous acceleration platform to effectively address the complete array of modeling requirements. Approach. In this paper we propose and build BrainFrame, a heterogeneous acceleration platform that incorporates three distinct acceleration technologies, an Intel Xeon-Phi CPU

    EXA2PRO programming environment:Architecture and applications

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    The EXA2PRO programming environment will integrate a set of tools and methodologies that will allow to systematically address many exascale computing challenges, including performance, performance portability, programmability, abstraction and reusability, fault tolerance and technical debt. The EXA2PRO tool-chain will enable the efficient deployment of applications in exascale computing systems, by integrating high-level software abstractions that offer performance portability and efficient exploitation of exascale systems' heterogeneity, tools for efficient memory management, optimizations based on trade-offs between various metrics and fault-tolerance support. Hence, by addressing various aspects of productivity challenges, EXA2PRO is expected to have significant impact in the transition to exascale computing, as well as impact from the perspective of applications. The evaluation will be based on 4 applications from 4 different domains that will be deployed in JUELICH supercomputing center. The EXA2PRO will generate exploitable results in the form of a tool-chain that support diverse exascale heterogeneous supercomputing centers and concrete improvements in various exascale computing challenges

    Применение метода контрольных возмущений для определения характерных узлов присоединения комплексной нагрузки при расчетах динамической устойчивости

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    Рассматривается влияние способа замещения комплексной нагрузки на характер электромеханических переходных процессов в электрических системах (ЭС) от действия больших возмущений. Показано, что установить общие рекомендации относительно способа замещения нагрузки в сложных ЭС затруднительно. Предлагается для опреде­ления характерных узлов нагрузки, оказывающих существенное влияние на характер динамического перехода, применять известный метод контрольных возмущений. Приводятся результаты сравнительных расчетов с использованием предлагаемой методики
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